P2X receptors trigger intracellular alkalization in isolated perfused mouse medullary thick ascending limb
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چکیده
منابع مشابه
P2X receptors trigger intracellular alkalization in isolated perfused mouse medullary thick ascending limb
AIMS Extracellular ATP is an important regulator of renal tubular transport. Recently, we found that basolateral ATP markedly inhibits Na(+) and Cl(-) absorption in mouse medullary thick ascending limb (mTAL) via a P2X receptor. The underlying mechanism that mediates this ATP-dependent transport inhibition in mTAL is, however, unclear. The renal outer medullary K(+) channel (ROMK) is sensitive ...
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متن کاملExtracellular ATP inhibits transport in medullary thick ascending limbs: role of P2X receptors.
Absorption of NaCl by the thick ascending limb (TAL) involves active transport and therefore depends on oxidative phosphorylation. Extracellular ATP has pleiotropic effects, including both stimulation and inhibition of transport and inhibition of oxidative phosphorylation. However, it is unclear whether ATP alters TAL transport and how this occurs. We hypothesized that ATP inhibits TAL Na absor...
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ژورنال
عنوان ژورنال: Acta Physiologica
سال: 2014
ISSN: 1748-1708,1748-1716
DOI: 10.1111/apha.12417